Publications

 

To view the paper click on the Journal webpage link!!!

 

1.      Jensen M.V., J.W. Joseph, S.M. Ronnebaum, S.C. Burgess, A.D. Sherry, C.B. Newgard (2008).  Metabolic Cycling in Control of Glucose-stimulated Insulin Secretion. Am J Physiol Endocrinol Metab. Aug 26. [Epub ahead of print].

 

2.      Ronnebaum S.M., J.W. Joseph, O. Ilkayeva, S.C. Burgess, D. Lu, T.C. Becker, A.D. Sherry, C.B. Newgard (2008). Chronic suppression of acetyl CoA carboxylase 1 in b-cells impairs insulin secretion via inhibition of glucose rather than lipid metabolism. Journal of Biological Chemistry 283(21):14248-56.

 

3.      Kimple M.E., J.W. Joseph, C.L. Bailey, P.T. Fueger, I.A. Hendry, C.B. Newgard, P.J. Casey (2008). Gα_Z negatively regulates insulin secretion and glucose clearance. Journal of Biological Chemistry 283(8) 4560-4567.

 

4.      Joseph J.W., M.L. Odegaard, S.M. Ronnebaum, S.C. Burgess, J. Muehlbauer, A.D. Sherry, C.B. Newgard (2007). Normal Flux through ATP-citrate lyase or fatty acid synthase is not required for glucose-stimulated insulin secretion. Journal of Biological Chemistry 282(43): 31592-31600. 

 

5.      Joseph J.W., M.V. Jensen, O. Ilkayeva, F. Palmieri, C. Alarcon, C.J. Rhodes, C.B. Newgard (2006). The mitochondrial citrate/isocitrate carrier plays a regulatory role in glucose-stimulated insulin secretion. Journal Biological Chemistry 281(47):35624-32.

 

6.      Ronnebaum S., O. Ilkayeva, S.C. Burgess, J.W. Joseph, D. Lu, R.E. Stevens, T.C. Becker, A.D. Sherry, C.B. Newgard, and M.V. Jensen (2006). A pyruvate cycling pathway involving cytosolic NADP-dependent isocitrate dehydrogenase and NADPH production regulates glucose-stimulated insulin secretion.  Journal of Biological Chemistry 281(41): 30593-30602.

 

7.        Jensen M.V., J.W. Joseph, S. Burgess, O. Ilkaveva, S. Ronnebaum, D. Lu, M. Odegaard, T.C. Becker, A.D. Sherry, C.B. Newgard (2006).  Compensatory Responses to Pyruvate Carboxylase Suppression in Islet β-cells: Preservation of Glucose-Stimulated Insulin Secretion.  Journal of Biological Chemistry 281(31): 22342-22351.

 

8.        McQuaid T.S., M.C. Saleh, J.W. Joseph, A. Gyulkhandanyan, J.E. Manning-Fox, J.D. Maclellan, M.B. Wheeler, C.B. Chan (2006) cAMP-mediated signaling normalizes glucose-stimulated insulin secretion in uncoupling protein-2 overexpressing β-cells. Journal of Endocrinology 190(3):669-80. 

 

9.        MacDonald P.E., J.W. Joseph, P. Rorsman (2005) Mechanisms mediating distal glucose-sensing in pancreatic b-cells.  Philos. Trans. R. Soc. Lond B Biol Sci. 360(1464):2211-25.

 

10.      Joseph, J.W., C.B. Chan, M.B. Wheeler (2005) UCP2 knockout mouse islets have lower oxygen consumption and faster oscillations in oxygen consumption. Canadian Journal of Diabetes 29(1):19-26.

 

11.      Joseph, J.W., V. Koshkin, M.C. Saleh, W.I. Sivitz, C.Y. Zhang, B.B. Lowell, C.B. Chan, M.B. Wheeler (2004) Free fatty acid-induced β-cell defects are dependent on uncoupling protein 2 expression.  Journal of Biological Chemistry 279(49):51049-56.

 

12.      Héron-Milhavet L., Haluzik M., Ibrahimi A., Yakar S., Kim D., Gavrilova O., Pack S., Jou W.C., Ibrahimi A., Kim H., Hunt D., Yau D., Asghar Z., Joseph J.W., Wheeler M.B., Abumrad N.A., LeRoith D.. (2004) Muscle-specific overexpression of CD36 reverses the insulin resistance and diabetes of MKR mice. Endocrinology 145(10):4667-4676.

 

13.      MacDonald P.E., J.W. Joseph, Patel M., Yau D., Asghar Z., Oudit G.Y., Backx P., M.B. Wheeler (2004) Defective glucose-stimulated insulin secretion in mice lacking the G-protein regulated p110g isoform of phosphoinositide 3-kinase.  Endocrinology 145:4078-4083.

 

14.      Kim, H., M. Haluzik, Z. Asghar, D. Yau, J.W. Joseph, A.M. Fernandez, M.L. Reitman, S. Yakar, B. Stannard, L. Heroin, M.B. Wheeler, D. LeRoith (2003) Peroxisome proliferator-activated receptor a (PPARa) agonist treatment of MKR mice with type 2 diabetes reverses the lipotoxic state and improves glucose homeostasis.  Diabetes 52:1770–1778.

 

15.      Kang, G., J.W. Joseph, O.G. Chepurny, M. Monaco, M.B. Wheeler, J.L. Bos, H Schwebe, H-G Genieser and G.G. Holz (2003) Epac-Selective cAMP analog 8-pCPT-2'-O-Me-cAMP as a stimulus for Ca²⁺-induced Ca²⁺ release and exocytosis in pancreatic b-Cells. Journal of Biological Chemistry 278(10):8279-8285.

 

16.      Joseph, J.W., V. Koshkin, C.B. Chan, C-Y. Zhang, B.B. Lowell, M.B. Wheeler (2002) UCP2 negatively regulates both insulin secretion and pancreatic b-cell compensation to a high fat diet. Diabetes 51(11):3211-9.

 

17.      MacDonald, P.E., S. Sewing, J. Wang, J.W. Joseph, S.R. Smukler, J. Wang, M.C. Saleh, C.B. Chan, A.M.F. Salapatek, R.G. Tsushima, M.B. Wheeler (2002) Inhibition of Kv2.1 voltage-dependent K⁺ channels in pancreatic β-cells enhances glucose-dependent insulin secretion. Journal of Biological Chemistry 277(47):44938-45.

 

18.      Chan, C.B., De Leo, D., J.W. Joseph, T.S. McQuaid, X.F. Xu, R.G. Tsushima, P.S. Pennefather, A.M. Salapatek, M.B. Wheeler (2001) Increased Uncoupling protein-2 levels in β-cells are associated with impaired glucose-stimulated insulin secretion: Mechanism of action. Diabetes, 50(6):1302-10.

 

19.      Joseph, J.W., Chan, C.B., Wheeler, M.B. (2001) β-cell Stimulus-Secretion Coupling and a Role for Uncoupling Protein 2.  Canadian Journal of Diabetes, 24(8).

 

20.      Joseph, J.W., J. Giguere, S. St.-Pierre, P. L. Brubaker (2000) Oral Delivery of a Glucagon-like peptide-1 in a modified polymer preparation normalizes basal glycemia in diabetic db/db mice. Diabetologia, 43(10):1319-28.