About Dr. Joseph

Jamie Joseph

Assistant Professor

Pharmaceutical Science

 

 

Dr. Joseph comes to the University of Waterloo after completing a CIHR post-doctoral fellowship at Duke University in Dr. Newgard’s laboratory. Dr. Newgard is the director of a world class diabetes and metabolism research center at Duke University in North Carolina. His work led to the discovery of a novel pathway involved in the regulation of insulin release from pancreatic b-cells called pyruvate-cycling. Prior to this Dr. Joseph did his PhD at the University of Toronto in Dr. Wheeler’s laboratory looking at the role of the inner mitochondrial membrane protein uncoupling protein-2 in pancreatic b-cell ATP production and insulin secretion. Dr. Joseph did his Master’s at the University of Toronto in Dr. Brubaker’s laboratory developing novel oral delivery systems for therapeutic peptides. Dr. Joseph’s laboratory at UW will focus on looking at the role of glucose in regulating insulin release from pancreatic b-cells.

 

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Experience

 

Duke University

 

Supervisor: Dr. C. Newgard (Department of Pharmacology and Cancer Biology)

Position: Postdoctorate Fellow

 

Introduction:  Metabolic regulation of insulin secretion in the pancreatic b-cell.

 

Project 1:  The role of the mitochondrial citrate carrier (CIC) in glucose-stimulated insulin secretion.

 

Project 2:  The role of the mitochondrial dicarboxylate carrier (DIC) in glucose-stimulated insulin secretion.

 

Project 3:  A Pyruvate Cycling Pathway Involving Cytosolic NADP-dependent Isocitrate Dehydrogenase and NADPH Production Regulates Glucose-Stimulated Insulin Secretion.

 

Project 4:  de novo production of Free fatty acids is not critical for glucose-stimulated insulin secretion.

 

Project 5:  The search for novel NADPH binding proteins that modulate insulin secretion.

 

Project 6:  Metabolic Regulation of Insulin Secretion: Importance of Pyruvate Carboxylase.

 

Do you want to learn more about Dr. Newgard (click here) or (click here)

Do you want to learn more about the Sarah Stedman Nutrition and Metabolism Center or the Metabolomics platform (click here)

 

 

Marine Biology Laboratories

 

Supervisor: Dr. Peter J.S. Smith

Position: Invited researcher

 

Project: Electrical coordination between distinct sites in the pancreas coincides with pulsatile insulin secretion in mice.

 

Do you want to learn more about Dr. P. Smith.

Do you want to learn more about the Biocurrents Research Center (click here)

 

 

University of Toronto

 

Supervisor: Dr. M. Wheeler (Department of Physiology)

Position: Ph.D. Student

 

Project: Characterization of pancreatic b-cell function in UCP-2 knockout mice.

 

Do you want to learn more about Dr. Wheeler (click here)

Do you want to learn more about the Endocrinology and Diabetes Research Grouping (click here)

 

 

University of Toronto

 

Supervisor: Dr. P. Brubaker (Department of Physiology)

Position: Master’s Student.

 

Project: Design of an oral GLP-1 delivery system for the treatment of type 2 diabetes.

 

Do you want to learn more about Dr. Brubaker (click here)

 

 

 

Defense and Civil Institute of Environmental Medicine (DCIEM)

     

Supervisor:  Dr. Bob Cheung (Department of Aerospace Life Support)

 

Project: Effects of sustained acceleration on human vestibulo-oculomotor responses.

 

 

 

University of Western Ontario

 

         

Supervisor: Dr. Stephen M. Sims (Department of Physiology)

 

Project:  Regulation of Ca²⁺-Dependent K⁺ Channels in Human smooth muscle cells.

 

Do you want to learn more about Dr. Sims (click here)

 

 

University of Western Ontario

 

 

Supervisor: Dr. Tim Zacharewski (Dept. of Pharmacology and Toxicology)

 

Project:  Development of a quantitative RT-PCR internal standard to assess murine Cytochrome P450-1A1 levels using site directed mutaqenesis.