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Rafael, J., Pampel, I., & Wang, X. (1994). Effect of pH and MgCl2 on the binding of purine nucleotides to the uncoupling protein in membrane particles from brown fat mitochondria. Eur.J Biochem 223, 971-980. Rashid, A., Wu, T. C., Huang, C. C., Chen, C. H., Lin, H. Z., Yang, S. Q., Lee, F. Y., & Diehl, A. M. (1999). Mitochondrial proteins that regulate apoptosis and necrosis are induced in mouse fatty liver. Hepatology 29, 1131-1138. Reaven, G. M. (1988). Role of insulin resistance in human disease. Diabetes 37, 1595-1607. Reaven, G. M., Hollenbeck, C., Jeng, C. Y., Wu, M. S., & Chen, Y. D. (1988). Measurement of plasma glucose, free fatty acid, lactate, and insulin for 24 h in patients with NIDDM. Diabetes 37, 1020-1024. Reusch, J. E. (2003). Diabetes, microvascular complications, and cardiovascular complications: what is it about glucose? J.Clin.Invest 112, 986-988. Rial, E., Gonzalez-Barroso, M. M., Fleury, C., & Bouillaud, F. (1998). The structure and function of the brown fat uncoupling protein UCP1: current status. Biofactors 8, 209-219. Rial, E., Poustie, A., & Nicholls, D. G. (1983). Brown-adipose-tissue mitochondria: the regulation of the 32000-Mr uncoupling protein by fatty acids and purine nucleotides. Eur.J Biochem 137, 197-203. Ricquier, D. & Bouillaud, F. (1997). The mitochondrial uncoupling protein: structural and genetic studies. Prog.Nucleic Acid Res.Mol.Biol 56, 83-108. Ricquier, D. & Bouillaud, F. (2000). The uncoupling protein homologues: UCP1, UCP2, UCP3 StUCP and AtUCP. Biochem J 345, 161-179. Ricquier, D., Lin, C., & Klingenberg, M. (1982). Isolation of the GDP binding protein from brown adipose tissue mitochondria of several animals and amino acid composition study in rat. Biochem Biophys.Res.Commun. 106, 582-589. Ritz-Laser, B., Meda, P., Constant, I., Klages, N., Charollais, A., Morales, A., Magnan, C., Ktorza, A., & Philippe, J. (1999). Glucose-induced preproinsulin gene expression is inhibited by the free fatty acid palmitate. Endocrinology 140, 4005-4014. Robertson, D. A., Singh, B. M., & Nattrass, M. (1991). Effect of obesity on circulating intermediary metabolite concentrations in the absence of impaired glucose tolerance. Int J Obes 15, 635-645. Robertson, R. P., Harmon, J., Tran, P. O., & Poitout, V. (2004). Beta-cell glucose toxicity, lipotoxicity, and chronic oxidative stress in type 2 diabetes. Diabetes 53 Suppl 1, S119-S124. Robertson, R. P., Harmon, J., Tran, P. O., Tanaka, Y., & Takahashi, H. (2003). Glucose toxicity in beta-cells: type 2 diabetes, good radicals gone bad, and the glutathione connection. Diabetes 52, 581-587. Robertson, R. P., Zhang, H. J., Pyzdrowski, K. L., & Walseth, T. F. (1992). Preservation of insulin mRNA levels and insulin secretion in HIT cells by avoidance of chronic exposure to high glucose concentrations. J.Clin.Invest 90, 320-325. Roche, E., Farfari, S., Witters, L. A., Assimacopoulos-Jeannet, F., Thumelin, S., Brun, T., Corkey, B. E., Saha, A. K., & Prentki, M. (1998). Long-term exposure of beta-INS cells to high glucose concentrations increases anaplerosis, lipogenesis, and lipogenic gene expression. Diabetes 47, 1086-1094. Roduit, R., Morin, J., Masse, F., Segall, L., Roche, E., Newgard, C. B., Assimacopoulos-Jeannet, F., & Prentki, M. (2000). Glucose down-regulates the expression of the peroxisome proliferator- activated receptor-alpha gene in the pancreatic beta -cell. J Biol Chem 275, 35799-35806. Rolfe, D. F. & Brand, M. D. (1996). Contribution of mitochondrial proton leak to skeletal muscle respiration and to standard metabolic rate. Am.J Physiol 271, C1380-C1389. Rolfe, D. F. & Brand, M. D. (1997). The physiological significance of mitochondrial proton leak in animal cells and tissues. Bioscience Reports 17, 9-16. Rolfe, D. F. & Brown, G. C. (1997). Cellular energy utilization and molecular origin of standard metabolic rate in mammals. Physiol Rev 77, 731-758. Rorsman, P., Eliasson, L., Renstrom, E., Gromada, J., Barg, S., & Gopel, S. (2000). The Cell Physiology of Biphasic Insulin Secretion. News Physiol Sci. 15, 72-77. Roseth, S., Fykse, E. M., & Fonnum, F. (1995). Uptake of L-glutamate into rat brain synaptic vesicles: effect of inhibitors that bind specifically to the glutamate transporter. J Neurochem. 65, 96-103. Rossini, A. A., Mordes, J. P., Greiner, D. L., & Stoff, J. S. (2001). Islet cell transplantation tolerance. Transplantation 72, S43-S46. Rousset, S., Alves-Guerra, M. C., Mozo, J., Miroux, B., Cassard-Doulcier, A. M., Bouillaud, F., & Ricquier, D. (2004). The biology of mitochondrial uncoupling proteins. Diabetes 53 Suppl 1, S130-S135. Rubi, B., Antinozzi, P. A., Herrero, L., Ishihara, H., Asins, G., Serra, D., Wollheim, C. B., Maechler, P., & Hegardt, F. G. (2002). Adenovirus-mediated overexpression of liver carnitine palmitoyltransferase I in INS1E cells: effects on cell metabolism and insulin secretion. Biochemical Journal 364, 219-226. Rutter, G. A. & Tsuboi, T. (2004). Kiss and run exocytosis of dense core secretory vesicles. Neuroreport 15, 79-81. Sakai, K., Matsumoto, K., Nishikawa, T., Suefuji, M., Nakamaru, K., Hirashima, Y., Kawashima, J., Shirotani, T., Ichinose, K., Brownlee, M., & Araki, E. (2003). Mitochondrial reactive oxygen species reduce insulin secretion by pancreatic beta-cells. Biochemical and Biophysical Research Communications 300, 216-222. Salapatek, A. M., MacDonald, P. E., Gaisano, H. Y., & Wheeler, M. B. (1999). Mutations to the third cytoplasmic domain of the glucagon-like peptide 1 (GLP-1) receptor can functionally uncouple GLP-1-stimulated insulin secretion in HIT-T15 cells. Mol.Endocrinol. 13, 1305-1317. Saltiel, A. R. (2001). New perspectives into the molecular pathogenesis and treatment of type 2 diabetes. Cell 104, 517-529. Saltiel, A. R. & Kahn, C. R. (2001). Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414, 799-806. Saltiel, A. R. & Olefsky, J. M. (1996). Thiazolidinediones in the treatment of insulin resistance and type II diabetes. Diabetes 45, 1661-1669. Samec, S., Seydoux, J., & Dulloo, A. G. (1998a). Interorgan signaling between adipose tissue metabolism and skeletal muscle uncoupling protein homologs: is there a role for circulating free fatty acids? Diabetes 47, 1693-1698. Samec, S., Seydoux, J., & Dulloo, A. G. (1998b). Role of UCP homologues in skeletal muscles and brown adipose tissue: mediators of thermogenesis or regulators of lipids as fuel substrate? FASEB J 12, 715-724. Samec, S., Seydoux, J., & Dulloo, A. G. (1998c). Role of UCP homologues in skeletal muscles and brown adipose tissue: mediators of thermogenesis or regulators of lipids as fuel substrate? FASEB Journal 12, 715-724. Sanchis, D., Fleury, C., Chomiki, N., Goubern, M., Huang, Q., Neverova, M., Gregoire, F., Easlick, J., Raimbault, S., Levi-Meyrueis, C., Miroux, B., Collins, S., Seldin, M., Richard, D., Warden, C., Bouillaud, F., & Ricquier, D. (1998). BMCP1, a novel mitochondrial carrier with high expression in the central nervous system of humans and rodents, and respiration uncoupling activity in recombinant yeast. Journal of Biological Chemistry 273, 34611-34615. Sanlioglu, S., Williams, C. M., Samavati, L., Butler, N. S., Wang, G., McCray, P. B., Jr., Ritchie, T. C., Hunninghake, G. W., Zandi, E., & Engelhardt, J. F. (2001). Lipopolysaccharide induces Rac1-dependent reactive oxygen species formation and coordinates tumor necrosis factor-alpha secretion through IKK regulation of NF-kappa B. Journal of Biological Chemistry 276, 30188-30198. Sasahara, M., Nishi, M., Kawashima, H., Ueda, K., Sakagashira, S., Furuta, H., Matsumoto, E., Hanabusa, T., Sasaki, H., & Nanjo, K. (2004). Uncoupling protein 2 promoter polymorphism -866G/A affects its expression in beta-cells and modulates clinical profiles of Japanese type 2 diabetic patients. Diabetes 53, 482-485. Scarpace, P. J., Nicolson, M., & Matheny, M. (1998). UCP2, UCP3 and leptin gene expression: modulation by food restriction and leptin. Journal of Endocrinology 159, 349-357. Schaffer, J. E. (2002). Fatty acid transport: the roads taken. Am.J.Physiol Endocrinol.Metab 282, E239-E246. Scheenen, W. J., Wollheim, C. B., Pozzan, T., & Fasolato, C. (1998). Ca2+ depletion from granules inhibits exocytosis. A study with insulin- secreting cells. J Biol Chem 273, 19002-19008. Schoonjans, K., Staels, B., & Auwerx, J. (1996). Role of the peroxisome proliferator-activated receptor (PPAR) in mediating the effects of fibrates and fatty acids on gene expression. J Lipid Res. 37, 907-925. Schrauwen, P. & Hesselink, M. (2002). UCP2 and UCP3 in muscle controlling body metabolism. J.Exp.Biol. 205, 2275-2285. Schuit, F., De Vos, A., Farfari, S., Pipeleers, D., Brun, T., & Prentki, M. (1997). Metabolic fate of glucose in purified islet cells. Glucose-regulated anaplerosis in beta cells. J Biol Chem 272, 18572-18579. Schultz, V., Sussman, I., Bokvist, K., & Tornheim, K. (1993). Bioluminometric assay of ADP and ATP at high ATP/ADP ratios: assay of ADP after enzymatic removal of ATP. Anal.Biochem. 215, 302-304. Segall, L., Lameloise, N., Assimacopoulos-Jeannet, F., Roche, E., Corkey, P., Thumelin, S., Corkey, B. E., & Prentki, M. (1999). Lipid rather than glucose metabolism is implicated in altered insulin secretion caused by oleate in INS-1 cells. American Journal of Physiology 277, E521-E528. Sekine, N., Cirulli, V., Regazzi, R., & et al. (1994). Low lactate dehydrogenase and high mitochondrial glycerol phosphate dehydrogenase in pancreatic b-cell: Potential role in nutrient sensing. J Biol Chem 269, 4895-4902. Sener, A., Kawazu, S., Hutton, J. C., Boschero, A. C., Devis, G., Somers, G., Herchuelz, A., & Malaisse, W. J. (1978). The stimulus-secretion coupling of glucose-induced insulin release. Effect of exogenous pyruvate on islet function. Biochem J 176, 217-232. Sener, A. & Malaisse, W. J. (1992). Hexose metabolism in pancreatic islets. Ca(2+)-dependent activation of the glycerol phosphate shuttle by nutrient secretagogues. J Biol Chem 267, 13251-13256. Sesti, G., Cardellini, M., Marini, M. A., Frontoni, S., D'Adamo, M., Del Guerra, S., Lauro, D., De Nicolais, P., Sbraccia, P., Del Prato, S., Gambardella, S., Federici, M., Marchetti, P., & Lauro, R. (2003). A common polymorphism in the promoter of UCP2 contributes to the variation in insulin secretion in glucose-tolerant subjects. Diabetes 52, 1280-1283. Shimabukuro, M., Koyama, K., Chen, G., Wang, M. Y., Trieu, F., Lee, Y., Newgard, C. B., & Unger, R. H. (1997a). Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc.Natl.Acad.Sci.U.S.A 94, 4637-4641. Shimabukuro, M., Zhou, Y. T., Lee, Y., & Unger, R. H. (1997b). Induction of uncoupling protein-2 mRNA by troglitazone in the pancreatic islets of Zucker diabetic fatty rats. Biochem Biophys.Res.Commun. 237, 359-361. Shimabukuro, M., Zhou, Y. T., Levi, M., & Unger, R. H. (1998). Fatty acid-induced beta cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci U.S.A 95, 2498-2502. Shimokawa, T., Kato, M., Watanabe, Y., Hirayama, R., Kurosaki, E., Shikama, H., & Hashimoto, S. (1998). In vivo effects of pioglitazone on uncoupling protein-2 and -3 mRNA levels in skeletal muscle of hyperglycemic KK mice. Biochem Biophys.Res.Commun. 251, 374-378. Shulman, G. I. (2000). Cellular mechanisms of insulin resistance. J Clin Invest 106, 171-176. Silva, J. E. & Rabelo, R. (1997). Regulation of the uncoupling protein gene expression. European Journal of Endocrinology 136, 251-264. Simpson, K. J., Lukacs, N. W., Colletti, L., Strieter, R. M., & Kunkel, S. L. (1997). Cytokines and the liver. J.Hepatol. 27, 1120-1132. Sivitz, W. I., Fink, B. D., & Donohoue, P. A. (1999). Fasting and leptin modulate adipose and muscle uncoupling protein: divergent effects between messenger ribonucleic acid and protein expression. Endocrinology 140, 1511-1519. Skelly, R. H., Bollheimer, L. C., Wicksteed, B. L., Corkey, B. E., & Rhodes, C. J. (1998). A distinct difference in the metabolic stimulus-response coupling pathways for regulating proinsulin biosynthesis and insulin secretion that lies at the level of a requirement for fatty acyl moieties. Biochem J 331 ( Pt 2), 553-561. Skulachev, V. P. (1996). Role of uncoupled and non-coupled oxidations in maintenance of safely low levels of oxygen and its one-electron reductants. Q.Rev Biophys. 29, 169-202. Skulachev, V. P. (1998). Uncoupling: new approaches to an old problem of bioenergetics. Biochim.Biophys.Acta 1363, 100-124. Skulachev, V. P. (1999). Anion carriers in fatty acid-mediated physiological uncoupling. J Bioenerg.Biomembr. 31, 431-445. Smith, P. J., Hammar, K., Porterfield, D. M., Sanger, R. H., & Trimarchi, J. R. (1999). Self-referencing, non-invasive, ion selective electrode for single cell detection of trans-plasma membrane calcium flux. Microsc.Res.Tech. 46, 398-417. Smukler, S. R., Tang, L., Wheeler, M. B., & Salapatek, A. M. (2002). Exogenous nitric oxide and endogenous glucose-stimulated beta-cell nitric oxide augment insulin release. Diabetes 51, 3450-3460. Sohal, R. S. & Weindruch, R. (1996). Oxidative stress, caloric restriction, and aging. Science 273, 59-63. Solanes, G., Vidal-Puig, A., Grujic, D., Flier, J. S., & Lowell, B. B. (1997). The human uncoupling protein-3 gene. Genomic structure, chromosomal localization, and genetic basis for short and long form transcripts. Journal of Biological Chemistry 272, 25433-25436. Solimena, M., Dirkx, R., Jr., Hermel, J. M., Pleasic-Williams, S., Shapiro, J. A., Caron, L., & Rabin, D. U. (1996). ICA 512, an autoantigen of type I diabetes, is an intrinsic membrane protein of neurosecretory granules. EMBO Journal 15, 2102-2114. Sollner, T., Whiteheart, S. W., Brunner, M., Erdjument-Bromage, H., Geromanos, S., Tempst, P., & Rothman, J. E. (1993). SNAP receptors implicated in vesicle targeting and fusion. Nature 362, 318-324. Sower, J. R. & Ebstein, M. (1995). Diabetes mellitus and associated hypertension, vascular disease, and nephropathy. Hypertension 26, 869-879. Spiegelman, B. M. (1998). PPAR-gamma: adipogenic regulator and thiazolidinedione receptor. Diabetes 47, 507-514. Stein, D. T., Esser, V., Stevenson, B. E., Lane, K. E., Whiteside, J. H., Daniels, M. B., Chen, S., & McGarry, J. D. (1996). Essentiality of circulating fatty acids for glucose-stimulated insulin secretion in the fasted rat. J Clin Invest 97, 2728-2735. Strieleman, P. J., Schalinske, K. L., & Shrago, E. (1985). Fatty acid activation of the reconstituted brown adipose tissue mitochondria uncoupling protein. J Biol Chem 260, 13402-13405. Stuart, J. A., Harper, J. A., Brindle, K. M., Jekabsons, M. B., & Brand, M. D. (2001). Physiological levels of mammalian uncoupling protein 2 do not uncouple yeast mitochondria. Journal of Biological Chemistry 276, 18633-18639. Stumvoll, M., Nurjhan, N., Periello, G., Dailery, G., & Derich, J. E. (1995). Metabolic effects of metformin in non-insulin-dependent diabetes mellitus. N Engl J Med 333, 550-555. Suzuki, M., Fujikura, K., Inagaki, N., Seino, S., & Takata, K. (1997). Localization of the ATP-sensitive K+ channel subunit Kir6.2 in mouse pancreas. Diabetes 46, 1440-1444. Swenne, I. & Andersson, A. (1984). Effect of genetic background on the capacity for islet cell replication in mice. Diabetologia 27, 464-467. Takahashi, N., Kishimoto, T., Nemoto, T., Kadowaki, T., & Kasai, H. (2002). Fusion pore dynamics and insulin granule exocytosis in the pancreatic islet. Science 297, 1349-1352. Tanaka, Y., Tran, P. O., Harmon, J., & Robertson, R. P. (2002). A role for glutathione peroxidase in protecting pancreatic beta cells against oxidative stress in a model of glucose toxicity. Proc.Natl.Acad.Sci.U.S.A 99, 12363-12368. Territo, P. R., Mootha, V. K., French, S. A., & Balaban, R. S. (2000). Ca(2+) activation of heart mitochondrial oxidative phosphorylation: role of the F(0)/F(1)-ATPase. Am J Cell Physiol 278, C423-C435. The Diabetes Control and Complications Trials Research Group (1993). The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin-dependent diabetes mellitus. N.Engl.J.Med. 329, 977-983. Tillmar, L., Carlsson, C., & Welsh, N. (2002). Control of insulin mRNA stability in rat pancreatic islets. Regulatory role of a 3'-untranslated region pyrimidine-rich sequence. J Biol Chem 277, 1099-1106. Tokunaga, C., Yoshino, K., & Yonezawa, K. (2004). mTOR integrates amino acid- and energy-sensing pathways. Biochemical and Biophysical Research Communications 313, 443-446. Tornheim, K. (1997). Are metabolic oscillations responsible for normal oscillatory insulin secretion? Diabetes 46, 1375-1380. Trocino, R. A., Akazawa, S., Ishibashi, M., Matsumoto, K., Matsuo, H., Yamamoto, H., Goto, S., Urata, Y., Kondo, T., & Nagataki, S. (1995). Significance of glutathione depletion and oxidative stress in early embryogenesis in glucose-induced rat embryo culture. Diabetes 44, 992-998. Tsuruzoe, K., Araki, E., Furukawa, N., Shirotani, T., Matsumoto, T., Kaneko, K., Motoshima, H., Yoshizato, K., Shirakami, A., Kishikawa, H., Miyazaki, J., & Shichiri, M. (1998). Creation and characterization of a mitochondrial DNA-depleted pancreatic B-cell line: impaired insulin secretion induced by glucose leucine and sulfonylureas. Diab 47, 621-631. Turner, R., Cull, C., & Holman, R. (1996). United Kingdom Prospective Diabetes Study 17: A 9-year update of a randomized, controlled trial on the effect of improved metabolic control on complications in non-insulin-dependent diabetes mellitus. Annals of Internal Medicine 124, 136-145. Turner, R., Hattersley, A., & Cook, J. (1992). Type II diabetes: Search for primary defects. Ann.Med. 24, 511-516. Unger, R. H. (1995). Lipotoxicity in the pathogenesis of obesity-dependent NIDDM. Genetic and clinical implications. Diabetes 44, 863-870. Unger, R. H. (1997). How obesity causes diabetes in Zucker diabetic fatty rats. Trends Endocrinol.Metab. 7, 276-282. Unger, R. H. (2002). Lipotoxic diseases. Annu.Rev.Med. 53, 319-336. Unger, R. H. & Zhou, Y. T. (2001). Lipotoxicity of beta-cells in obesity and in other causes of fatty acid spillover. Diabetes 50 Suppl 1, S118-S121. Unger, R. H., Zhou, Y. T., & Orci, L. (1999a). Regulation of fatty acid homeostasis in cells: novel role of leptin. Proc.Natl.Acad.Sci.U.S.A 96, 2327-2332. Unger, R. H., Zhou, Y. T., & Orci, L. (1999b). Regulation of fatty acid homeostasis in cells: novel role of leptin. Proc Natl Acad Sci U.S.A 96, 2327-2332. Vidal-Puig, A., Rosenbaum, M., Considine, R. C., Leibel, R. L., Dohm, G. L., & Lowell, B. B. (1999). Effects of obesity and stable weight reduction on UCP2 and UCP3 gene expression in humans. Obes.Res. 7, 133-140. Vidal-Puig, A., Solanes, G., Grujic, D., Flier, J. S., & Lowell, B. B. (1997). UCP3: an uncoupling protein homologue expressed preferentially and abundantly in skeletal muscle and brown adipose tissue. Biochemical and Biophysical Research Communications 235, 79-82. Vidal-Puig, A. J., Grujic, D., Zhang, C. Y., Hagen, T., Boss, O., Ido, Y., Szczepanik, A., Wade, J., Mootha, V., Cortright, R., Muoio, D. M., & Lowell, B. B. (2000). Energy metabolism in uncoupling protein 3 gene knockout mice. J Biol Chem 275, 16258-16266. Viguerie-Bascands, N., Saulnier-Blache, J. S., Dandine, M., Dauzats, M., Daviaud, D., & Langin, D. (1999). Increase in uncoupling protein-2 mRNA expression by BRL49653 and bromopalmitate in human adipocytes. Biochem Biophys.Res.Commun. 256, 138-141. Walder, K., Norman, R. A., Hanson, R. L., Schrauwen, P., Neverova, M., Jenkinson, C. P., Easlick, J., Warden, C. H., Pecqueur, C., Raimbault, S., Ricquier, D., Silver, M. H. K., Shuldiner, A. R., Solanes, G., Lowell, B. B., Chung, W. K., Leibel, R. L., Pratley, R., & Ravussin, E. (1998). Association between uncoupling protein polymorphisms (UCP2-UCP3) and energy metabolism/obesity in Pima indians. Hum.Mol.Genet. 7, 1431-1435. Walker, J. E. & Runswick, M. J. (1993). The mitochondrial transport protein superfamily. J Bioenerg.Biomembr. 25, 435-446. Wallace, D. C. (1992). Diseases of the mitochondrial DNA. Annu.Rev Biochem 61, 1175-1212. Wang, M. Y., Koyama, K., Shimabukuro, M., Newgard, C. B., & Unger, R. H. (1998). OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype. Proc.Natl.Acad.Sci.U.S.A 95, 714-718. Wang, M. Y., Shimabukuro, M., Lee, Y., Trinh, K. Y., Chen, J. L., Newgard, C. B., & Unger, R. H. (1999). Adenovirus-mediated overexpression of uncoupling protein-2 in pancreatic islets of Zucker diabetic rats increases oxidative activity and improves beta-cell function. Diabetes 48, 1020-1025. Ward, M. W., Rego, A. C., Frenguelli, B. G., & Nicholls, D. G. (2000). Mitochondrial membrane potential and glutamate excitotoxicity in cultured cerebellar granule cells. Journal of Neuroscience 20, 7208-7219. Weigle, D. S., Selfridge, L. E., Schwartz, M. W., Seeley, R. J., Cummings, D. E., Havel, P. J., Kuijper, J. L., & Beltrandelrio, H. (1998). Elevated free fatty acids induce uncoupling protein 3 expression in muscle: a potential explanation for the effect of fasting. Diabetes 47, 298-302. Weiss, J. N. & Lamp, S. T. (1989). Cardiac ATP-sensitive K+ channels. Evidence for preferential regulation by glycolysis. J Gen Physiol 94, 911-935. Wheeler, M. B., Sheu, L., Ghai, M., Bouquillon, A., Grondin, G., Weller, U., Beaudoin, A. R., Bennett, M. K., Trimble, W. S., & Gaisano, H. Y. (1996). Characterization of SNARE protein expression in b cell lines and pancreatic islets. Endocrinology 137, 1340-1348. Willson, T. M. & Wahli, W. (1997). Peroxisome proliferator-activated receptor agonists. Curr.Opin.Chem Biol 1, 235-241. Winkler, E. & Klingenberg, M. (1994). Effect of fatty acids on H+ transport activity of the reconstituted uncoupling protein. J Biol Chem 269, 2508-2515. Wyllie, A. H., Kerr, J. F., & Currie, A. R. (1980). Cell death: the significance of apoptosis. Int Rev Cytol. 68, 251-306. Xu, B., Moritz, J. T., & Epstein, P. N. (1999). Overexpression of catalase provides partial protection to transgenic mouse beta cells. Free Radic.Biol.Med. 27, 830-837. Yang, S., Zhu, H., Li, Y., Lin, H., Gabrielson, K., Trush, M. A., & Diehl, A. M. (2000). Mitochondrial adaptations to obesity-related oxidant stress. Arch.Biochem Biophys. 378, 259-268. Yerneni, K. K., Bai, W., Khan, B. V., Medford, R. M., & Natarajan, R. (1999). Hyperglycemia-induced activation of nuclear transcription factor kappaB in vascular smooth muscle cells. Diabetes 48, 855-864. Yoon, J.-W., Yoon, C.-S., Lim, H.-W., Huang, Q. Q., Kang, Y., Pyun, K. H., Hirasawa, K., Sherwin, R. S., & Jun, H.-S. (1999). Control of autoimmune diabetes in NOD mice by GAD expression or suppression in B-cells. Science 284, 1183-1187. Zawalich, W. S. & Zawalich, K. C. (1997). Influence of pyruvic acid methyl ester on rat pancreatic islets. Effects on insulin secretion, phosphoinositide hydrolysis, and sensitization of the beta cell. J Biol Chem 272, 3527-3531. Zhang, C. Y., Baffy, G., Perret, P., Krauss, S., Peroni, O., Grujic, D., Hagen, T., Vidal-Puig, A. J., Boss, O., Kim, Y. B., Zheng, X. X., Wheeler, M. B., Shulman, G. I., Chan, C. B., & Lowell, B. B. (2001). Uncoupling protein-2 negatively regulates insulin secretion and is a major link between obesity, beta cell dysfunction, and type 2 diabetes. Cell 105, 745-755. Zhao, C., Wilson, M. C., Schuit, F., Halestrap, A. P., & Rutter, G. A. (2001). Expression and distribution of lactate/monocarboxylate transporter isoforms in pancreatic islets and the exocrine pancreas. Diabetes 50, 361-366. Zhou, Y. P. & Grill, V. (1995). Long term exposure to fatty acids and ketones inhibits B-cell functions in human pancreatic islets of Langerhans. J Clin Endocrinol.Metab 80, 1584-1590. Zhou, Y. P., Ling, Z. C., & Grill, V. E. (1996). Inhibitory effects of fatty acids on glucose-regulated B-cell function: Association with increased islet triglyceride stores and altered effect of fatty acid oxidation on glucose metabolism. Metabolism-Clinical and Experimental 45, 981-986. Zhou, Y. T., Shimabukuro, M., Koyama, K., Lee, Y., Wang, M. Y., Trieu, F., Newgard, C. B., & Unger, R. H. (1997). Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. Proc.Natl.Acad.Sci.U.S.A 94, 6386-6390. |